Psychosis and Cannabis Induced Psychosis; Paranoia; Schizophrenia; The two biggest things about Weed and Schizophrenia; The Chicken or the Egg problem; Depression, Anxiety and Bipolar Disorder, Distress Tolerance and Cannabis
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Refs. 350-431
350. Gage SH, Hickman M, Zammit S. Association Between Cannabis and Psychosis: Epidemiologic Evidence. Biol Psychiatry. 2016;79(7):549-56. PubMed PMID: 26386480.
351. Moore TH, Zammit S, Lingford-Hughes A, Barnes TR, Jones PB, Burke M, et al. Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet. 2007;370(9584):319-28. PubMed PMID: 17662880.
352. Sideli L, Quigley H, La Cascia C, Murray RM. Cannabis Use and the Risk of Psychosis and Affective Disorders. J Dual Diagn. 2019:1-21. PubMed PMID: 31647377.
353. Hall W, Degenhardt L. Cannabis use and the risk of developing a psychotic disorder. World Psychiatry. 2008;7(2):68-71. PubMed PMID: 18560513; PubMed Central PMCID: 2424288. FREE
354. Psychosis NIMH. Available from: https://www.nimh.nih.gov/health/topics/schizophrenia/raise/raise-questions-and-answers.shtml#1.
355. Psychosis Wikipedia. Available from: https://en.wikipedia.org/wiki/Psychosis.
356. Thomas H. Psychiatric symptoms in cannabis users. Br J Psychiatry. 1993;163:141-9. PubMed PMID: 8075903.
357. Shah D, Chand P, Bandawar M, Benegal V, Murthy P. Cannabis induced psychosis and subsequent psychiatric disorders. Asian J Psychiatr. 2017;30:180-4. PubMed PMID: 29096386.
358. Johns A. Psychiatric effects of cannabis. Br J Psychiatry. 2001;178:116-22. PubMed PMID: 11157424.
359. Ruby S. Grewal MD TPG, MD. Cannabis-Induced Psychosis: A Review Psychiatric times2017. Available from: https://www.psychiatrictimes.com/substance-use-disorder/cannabis-induced-psychosis-review.
360. Tunving K. Psychiatric effects of cannabis use. Acta Psychiatr Scand. 1985;72(3):209-17. PubMed PMID: 3000137.
361. Di Forti M, Quattrone D, Freeman TP, Tripoli G, Gayer-Anderson C, Quigley H, et al. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. Lancet Psychiatry. 2019;6(5):427-36. PubMed PMID: 30902669.
362. Gerlach J, Koret B, Geres N, Matic K, Prskalo-Cule D, Zadravec Vrbanc T, et al. Clinical Challenges in Patients with First Episode Psychosis and Cannabis Use: Mini-Review and a Case Study. Psychiatr Danub. 2019;31(Suppl 2):162-70. PubMed PMID: 31158117.
363. Arendt M, Rosenberg R, Foldager L, Perto G, Munk-Jorgensen P. Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases. Br J Psychiatry. 2005;187:510-5. PubMed PMID: 16319402.
364. Henquet C, Rosa A, Delespaul P, Papiol S, Fananas L, van Os J, et al. COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of ‘switching on’ hallucinations in the flow of daily life. Acta Psychiatr Scand. 2009;119(2):156-60. PubMed PMID: 18808401.
365. Vaessen TSJ, de Jong L, Schafer AT, Damen T, Uittenboogaard A, Krolinski P, et al. The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta – analysis. PLoS One. 2018;13(2):e0192658. PubMed PMID: 29444152; PubMed Central PMCID: 5812637. FREE
367. Mane A, Berge D, Penzol MJ, Parellada M, Bioque M, Lobo A, et al. Cannabis use, COMT, BDNF and age at first-episode psychosis. Psychiatry Res. 2017;250:38-43. PubMed PMID: 28142064.
368. Murrie B, Lappin J, Large M, Sara G. Transition of Substance-Induced, Brief, and Atypical Psychoses to Schizophrenia: A Systematic Review and Meta-analysis. Schizophr Bull. 2019. PubMed PMID: 31618428.
369. Paranoia- Wikipedia [9/1/2020]. Available from: https://en.wikipedia.org/wiki/Paranoia.
370. Freeman D, McManus S, Brugha T, Meltzer H, Jenkins R, Bebbington P. Concomitants of paranoia in the general population. Psychol Med. 2011;41(5):923-36. PubMed PMID: 20735884.
371. Freeman D, Morrison PD, Murray RM, Evans N, Lister R, Dunn G. Persecutory ideation and a history of cannabis use. Schizophr Res. 2013;148(1-3):122-5. PubMed PMID: 23806582.
372. Coid JW, Ullrich S, Bebbington P, Fazel S, Keers R. Paranoid Ideation and Violence: Meta-analysis of Individual Subject Data of 7 Population Surveys. Schizophr Bull. 2016;42(4):907-15.. PubMed PMID: 26884548; PubMed Central PMCID: 4903063. FREE
373. Schizophrenia-Wikipedia [9/1/2020]. Available from: https://en.wikipedia.org/wiki/Schizophrenia.
374. Kendler KS, Ohlsson H, Sundquist J, Sundquist K. Prediction of Onset of Substance-Induced Psychotic Disorder and Its Progression to Schizophrenia in a Swedish National Sample. Am J Psychiatry. 2019;176(9):711-9. PubMed PMID: 31055966; PubMed CentralPMCID: 6718312. FREE
375. Owen MJ, Sawa A, Mortensen PB. Schizophrenia. Lancet. 2016;388(10039):86-97. PubMed PMID: 26777917; PubMed Central PMCID: 4940219. FREE
376. Boksa P. Abnormal synaptic pruning in schizophrenia: Urban myth or reality? J Psychiatry Neurosci. 2012;37(2):75-7. PubMed PMID: 22339991; PubMed Central PMCID: 3297065. FREE
377. Blest-Hopley G, Colizzi M, Giampietro V, Bhattacharyya S. Is the Adolescent Brain at Greater Vulnerability to the Effects of Cannabis? A Narrative Review of the Evidence. Front Psychiatry. 2020;11:859. PubMed PMID: 33005157; PubMed Central PMCID: 7479242. FREE
378. Evensen S., Wisløff T., Lystad J.U. , Bull H., Ueland T., and Falkum E. Prevalence, Employment Rate, and Cost of Schizophrenia in a High-Income Welfare Society: A Population-Based Study Using Comprehensive Health and Welfare Registers. Schizophr Bull. 2016 Mar; 42(2): 476–483.PubMed PMID: 26433216 PubMed Central PMCID: 4753607 FREE
379. Andreasson S, Allebeck P, Engstrom A, Rydberg U. Cannabis and schizophrenia. A longitudinal study of Swedish conscripts. Lancet. 1987;2(8574):1483-6. PubMed PMID: 2892048.
380. Hjorthoj C, Albert N, Nordentoft M. Association of Substance Use Disorders With Conversion From Schizotypal Disorder to Schizophrenia. JAMA Psychiatry. 2018;75(7):733-9. PubMed PMID: 29710317; PubMed Central PMCID: 6145672. FREE
381. Khantzian EJ. The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. Harv Rev Psychiatry. 1997;4(5):231-44. PubMed PMID: 9385000.
382 Kolliakou A, Joseph C, Ismail K, Atakan Z, Murray RM. Why do patients with psychosis use cannabis and are they ready to change their use? Int J Dev Neurosci. 2011;29(3):335-46. PubMed PMID: 21172414.
383. Hall W. Cannabis use and psychosis. Drug Alcohol Rev. 1998;17(4):433-44. PubMed PMID: 16203510.
384. Griffith-Lendering MF, Wigman JT, Prince van Leeuwen A, Huijbregts SC, Huizink AC, Ormel J, et al. Cannabis use and vulnerability for psychosis in early adolescence–a TRAILS study. Addiction. 2013;108(4):733-40. PubMed PMID: 23216690.
385. Arseneault L, Cannon M, Poulton R, Murray R, Caspi A, Moffitt TE. Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. BMJ. 2002;325(7374):1212-3. PubMed PMID: 12446537; PubMed Central PMCID: 135493. FREE
386. Kuepper R, van Os J, Lieb R, Wittchen HU, Hofler M, Henquet C. Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study. BMJ. 2011;342:d738. PubMed PMID: 21363868; PubMed Central PMCID: 3047001. FREE
387. Bourque J, Afzali MH, Conrod PJ. Association of Cannabis Use With Adolescent Psychotic Symptoms. JAMA Psychiatry. 2018;75(8):864-6. PubMed PMID: 29874357; PubMed Central PMCID: 6584279. FREE
388. Compton MT, Kelley ME, Ramsay CE, Pringle M, Goulding SM, Esterberg ML, et al. Association of pre-onset cannabis, alcohol, and tobacco use with age at onset of prodrome and age at onset of psychosis in first-episode patients. Am J Psychiatry. 2009;166(11):1251-7. PubMed PMID: 19797432; PubMed Central PMCID: 3662470. FREE
389. Neill E, Tan EJ, Toh WL, Selvendra A, Morgan VA, Rossell SL, et al. Examining which factors influence age of onset in males and females with schizophrenia. Schizophr Res. 2020. PubMed PMID: 32883558.
390. Gage SH, Jones HJ, Burgess S, Bowden J, Davey Smith G, Zammit S, et al. Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study. Psychol Med. 2017;47(5):971-80. PubMed PMID: 27928975; PubMed Central PMCID: 5341491. FREE
391. Clausen L, Hjorthoj CR, Thorup A, Jeppesen P, Petersen L, Bertelsen M, et al. Change in cannabis use, clinical symptoms and social functioning among patients with first-episode psychosis: a 5-year follow-up study of patients in the OPUS trial. Psychol Med. 2014;44(1):117-26. PubMed PMID: 23590927.
392. Schoeler T, Petros N, Di Forti M, Pingault JB, Klamerus E, Foglia E, et al. Association Between Continued Cannabis Use and Risk of Relapse in First-Episode Psychosis: A Quasi-Experimental Investigation Within an Observational Study. JAMA Psychiatry. 2016;73(11):1173-9. PubMed PMID: 27680429.
393. Hatzigiakoumis DS, Martinotti G, Giannantonio MD, Janiri L. Anhedonia and substance dependence: clinical correlates and treatment options. Front Psychiatry. 2011;2:10. PubMed PMID: 21556280; PubMed Central PMCID: 3089992. FREE
394. Gobbi G, Atkin T, Zytynski T, Wang S, Askari S, Boruff J, et al. Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2019;76(4):426-34. PubMed PMID: 30758486; PubMed Central PMCID: 6450286. FREE
395. Esmaeelzadeh S, Moraros J, Thorpe L, Bird Y. The association between depression, anxiety and substance use among Canadian post-secondary students. Neuropsychiatr Dis Treat. 2018;14:3241-51. PubMed PMID: 30538482; PubMed Central PMCID: 6260190. FREE
396. Horwood LJ, Fergusson DM, Coffey C, Patton GC, Tait R, Smart D, et al. Cannabis and depression: an integrative data analysis of four Australasian cohorts. Drug Alcohol Depend. 2012;126(3):369-78. PubMed PMID: 22749560.
397. Lev-Ran S, Roerecke M, Le Foll B, George TP, McKenzie K, Rehm J. The association between cannabis use and depression: a systematic review and meta-analysis of longitudinal studies. Psychol Med. 2014;44(4):797-810. PubMed PMID: 23795762.
398. Gukasyan N, Strain EC. Relationship between cannabis use frequency and major depressive disorder in adolescents: Findings from the National Survey on Drug Use and Health 2012-2017. Drug Alcohol Depend. 2020;208:107867. PubMed PMID: 31958677; PubMed Central PMCID: 7039755. FREE
3929 Van Ameringen M, Zhang J, Patterson B, Turna J. The role of cannabis in treating anxiety: an update. Curr Opin Psychiatry. 2020;33(1):1-7. PubMed PMID: 31688192.
400. Volkow ND, Hampson AJ, Baler RD. Don’t Worry, Be Happy: Endocannabinoids and Cannabis at the Intersection of Stress and Reward. Annu Rev Pharmacol Toxicol. 2017;57:285-308. PubMed PMID: 27618739.
401. Anxiety Anxiety.org [9/11/2020]. Available from: https://www.anxiety.org/what-is-anxiety.
402. NAMI Anxiety Disorders [9/11/2020]. Available from: https://www.nami.org/About-Mental-Illness/Mental-Health-Conditions/Anxiety-Disorders.
403. Anxiety disorders Mayo Clinic [9/11/2020]. Available from: https://www.mayoclinic.org/diseases-conditions/anxiety/symptoms-causes/syc-20350961.
404 Turna J, Patterson B, Van Ameringen M. Is cannabis treatment for anxiety, mood, and related disorders ready for prime time? Depress Anxiety. 2017;34(11):1006-17. PubMed PMID: 28636769.
405. Bonini SA, Premoli M, Tambaro S, Kumar A, Maccarinelli G, Memo M, et al. Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. J Ethnopharmacol. 2018;227:300-15. PubMed PMID: 30205181.
406. Ramikie TS, Patel S. Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress. Neuroscience. 2012;204:38-52. . PubMed PMID: 21884761; PubMed Central PMCID: 3236282. FREE
407. Masataka N. Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders. Front Psychol. 2019;10:2466. PubMed PMID: 31787910; PubMed Central PMCID: 6856203. FREE
408. Lim K, See YM, Lee J. A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders. Clin Psychopharmacol Neurosci. 2017;15(4):301-12. PubMed PMID: 29073741; PubMed Central PMCID: 5678490. FREE
409. Childs E, Lutz JA, de Wit H. Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress. Drug Alcohol Depend. 2017;177:136-44. PubMed PMID: 28599212; PubMed Central PMCID: 6349031. FREE
410. Bossong MG, Jansma JM, van Hell HH, Jager G, Kahn RS, Ramsey NF. Default mode network in the effects of Delta9-Tetrahydrocannabinol (THC) on human executive function. PLoS One. 2013;8(7):e70074. PubMed PMID: 23936144; PubMed Central PMCID: 3729458. FREE
411. Fusar-Poli P, Allen P, Bhattacharyya S, Crippa JA, Mechelli A, Borgwardt S, et al. Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. Int J Neuropsychopharmacol. 2010;13(4):421-32. PubMed PMID: 19775500.
412. Feingold D, Weiser M, Rehm J, Lev-Ran S. The association between cannabis use and anxiety disorders: Results from a population-based representative sample. Eur Neuropsychopharmacol. 2016;26(3):493-505. PubMed PMID: 26775742.
413. Degenhardt L, Coffey C, Romaniuk H, Swift W, Carlin JB, Hall WD, et al. The persistence of the association between adolescent cannabis use and common mental disorders into young adulthood. Addiction. 2013;108(1):124-33. PubMed PMID: 22775447.
414. Hall W, Solowij N. Adverse effects of cannabis. Lancet. 1998;352(9140):1611-6. PubMed PMID: 9843121.
410. Roy-Byrne PP, Uhde TW. Exogenous factors in panic disorder: clinical and research implications. J Clin Psychiatry. 1988;49(2):56-61. PubMed PMID: 3276668.
415. Tournier M, Sorbara F, Gindre C, Swendsen JD, Verdoux H. Cannabis use and anxiety in daily life: a naturalistic investigation in a non-clinical population. Psychiatry Res. 2003;118(1):1-8. PubMed PMID: 12759155.
416. Hollister LE. Health aspects of cannabis. Pharmacol Rev. 1986;38(1):1-20. Epub 1986/03/01. PubMed PMID: 3520605.
417. Smaga I, Bystrowska B, Gawlinski D, Przegalinski E, Filip M. The endocannabinoid/endovanilloid system and depression. Curr Neuropharmacol. 2014;12(5):462-74. PubMed PMID: 25426013; PubMed Central PMCID: 4243035. FREE
418. Hirvonen J, Goodwin RS, Li CT, Terry GE, Zoghbi SS, Morse C, et al. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry. 2012;17(6):642-9. PubMed PMID: 21747398; PubMed Central PMCID: 3223558. FREE
419. Suplita RL, 2nd, Eisenstein SA, Neely MH, Moise AM, Hohmann AG. Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia. Neuropharmacology. 2008;54(1):161-71.PubMed PMID: 17714742; PubMed Central PMCID: 2771679. FREE
420. Mayer TA, Matar MA, Kaplan Z, Zohar J, Cohen H. Blunting of the HPA-axis underlies the lack of preventive efficacy of early post-stressor single-dose Delta-9-tetrahydrocannabinol (THC). Pharmacol Biochem Behav. 2014;122:307-18. PubMed PMID: 24814135.
421. Beyer CE, Dwyer JM, Piesla MJ, Platt BJ, Shen R, Rahman Z, et al. Depression-like phenotype following chronic CB1 receptor antagonism. Neurobiol Dis. 2010;39(2):148-55. PubMed PMID: 20381618.
422. Kedzior KK, Laeber LT. A positive association between anxiety disorders and cannabis use or cannabis use disorders in the general population–a meta-analysis of 31 studies. BMC Psychiatry. 2014;14:136. PubMed PMID: 24884989; PubMed Central PMCID: 4032500. FREE
423. Distress Tolerance-Very Well MInd [8/20/20]. Available from: https://www.verywellmind.com/distress-tolerance-2797294.
424. Distress Tolerance- Wikipedia [8/20-2020]. Available from: https://en.wikipedia.org/wiki/Distress_tolerance.
425. Peraza N, Smit T, Garey L, Manning K, Buckner JD, Zvolensky MJ. Distress tolerance and cessation-related cannabis processes: The role of cannabis use coping motives. Addict Behav. 2019;90:164-70. PubMed PMID: 30408699.
426. Dialectic Behaviour Therapy- Wikipedia [8/20/2020]. Available from: https://en.wikipedia.org/wiki/Dialectical_behavior_therapy.
427. Dimeff LA, Linehan MM. Dialectical behavior therapy for substance abusers. Addict Sci Clin Pract. 2008;4(2):39-47. PubMed PMID: 18497717; PubMed Central PMCID: 2797106. FREE
428. Bipolar Disorder-Mayo Clinic [8/21/2020]. Available from: https://www.mayoclinic.org/diseases-conditions/bipolar-disorder/symptoms-causes/syc-20355955.
429. Gibbs M, Winsper C, Marwaha S, Gilbert E, Broome M, Singh SP. Cannabis use and mania symptoms: a systematic review and meta-analysis. J Affect Disord. 2015;171:39-47. PubMed PMID: 25285897.
430. van Laar M, van Dorsselaer S, Monshouwer K, de Graaf R. Does cannabis use predict the first incidence of mood and anxiety disorders in the adult population? Addiction. 2007;102(8):1251-60. PubMed PMID: 17624975.
431. Mammen G, Rueda S, Roerecke M, Bonato S, Lev-Ran S, Rehm J. Association of Cannabis With Long-Term Clinical Symptoms in Anxiety and Mood Disorders: A Systematic Review of Prospective Studies. J Clin Psychiatry. 2018;79(4). PubMed PMID: 29877641.