Chapter 3: Things to know about weed

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The Big 4-How early, How often, How much, How strong; Low Dose /High Dose – Short Term /Long Term use; People are different; This is not the marijuana of the 1969 Woodstock generation

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Refs. 11-42

11.Johnston LD, O’Malley PM, Miech RA, Bachman JG, Schulenberg JE. Monitoring the Future national survey results on drug use, 1975–2015: Overview, key findings on adolescent drug use. Ann Arbor: Institute for Social Research, The University of Michigan; 2016.

12. Rioux, C., Castellanos-Ryan N., Parent, S., Vitaro, F., Tremblay, R.E., and Séguin, J.R. Age of Cannabis Use Onset and Adult Drug Abuse Symptoms: A Prospective Study of Common Risk Factors and Indirect Effects. Can J Psychiatry 2018 Jul;63(7):457-464. PubMed PMID29682999_PubMed Central PMC6099774 FREE

13. Galvez-Buccollini, J.A., Proal A.C., Tomaselli V., Trachtenberg M., Coconcea C., Chun J., Manschreck T., Fleming J., Delisi L.E. Association between age at onset of psychosis and age at onset of cannabis use in non-affective psychosis. Schizophr Res. 2012 Aug;139(1-3):157-60. PubMed PMID22727454 PubMed Central PMC3415971 FREE

14. Hosseini S., and Oremus M. he Effect of Age of Initiation of Cannabis Use on Psychosis, Depression, and Anxiety among Youth under 25 Years. Can J Psychiatry. 2019 May;64(5):304-312. PubMED PMID30373388_PubMed Central PMC6591882 FREE

15. Harvey PD. Smoking Cannabis and Acquired Impairments in Cognition: Starting Early Seems Like a Really Bad Idea. Am J Psychiatry. 2019;176(2):90-1. PubMed PMID: 30704281.

16. Volkow ND, Swanson JM, Evins AE, DeLisi LE, Meier MH, Gonzalez R, et al. Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review. JAMA Psychiatry. 2016;73(3):292-7. PubMed PMID: 26842658. FREE

17. Earleywine M, Luba, R., Slavin, M. N., Farmer, S. & Loflin, M. Don’t wake and bake: morning use predicts cannabis problems. . Addict Res Theory. 2016;24:426–30.

18. Heard K, Monte AA, Hoyte CO. Brief Commentary: Consequences of Marijuana-Observations From the Emergency Department. Ann Intern Med. 2019;170(2):124. PubMed PMID: 30615784; PubMed Central PMCID: 6669097. FREE

19. Hall KE, Monte AA, Chang T, Fox J, Brevik C, Vigil DI, et al. Mental Health-related Emergency Department Visits Associated With Cannabis in Colorado. Acad Emerg Med. 2018;25(5):526-37. PubMed PMID: 29476688; PubMed Central PMCID: 5980767. FREE

20. Roberts BA. Legalized Cannabis in Colorado Emergency Departments: A Cautionary Review of Negative Health and Safety Effects. West J Emerg Med. 2019;20(4):557-72. PubMed PMID: 31316694; PubMed Central PMCID: 6625695. FREE

21. Bhattacharyya S, Morrison PD, Fusar-Poli P, Martin-Santos R, Borgwardt S, Winton-Brown T, et al. Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology. 2010;35(3):764-74. PubMed PMID: 19924114; PubMed Central PMCID: 3055598. FREE

23. Hjorthoj C, Posselt CM. Delta(9)-tetrahydrocannabinol: harmful even in low doses? Lancet Psychiatry. 2020;7(4):296-7. PubMed PMID: 32197091.

24. Hindley G, Beck K, Borgan F, Ginestet CE, McCutcheon R, Kleinloog D, et al. Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis. Lancet Psychiatry. 2020;7(4):344-53. PubMed PMID: 32197092.

25. Dose-Response Relationship Wikipedia []. Available from:–response_relationship

26. Marconi A, Di Forti M, Lewis CM, Murray RM, Vassos E. Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis. Schizophr Bull. 2016;42(5):1262-9. PubMed PMID: 26884547; PubMed Central PMCID: 4988731. FREE

27. Ramaekers JG, van Wel JH, Spronk DB, Toennes SW, Kuypers KP, Theunissen EL, et al. Cannabis and tolerance: acute drug impairment as a function of cannabis use history. Sci Rep. 2016;6:26843.PubMed PMID: 27225696; PubMed Central PMCID: 4881034. FREE

28. Curran HV, Brignell C, Fletcher S, Middleton P, Henry J. Cognitive and subjective dose-response effects of acute oral Delta 9-tetrahydrocannabinol (THC) in infrequent cannabis users. Psychopharmacology (Berl). 2002;164(1):61-70. PubMed PMID: 12373420.

29. Ramaekers JG, Kauert G, van Ruitenbeek P, Theunissen EL, Schneider E, Moeller MR. High-potency marijuana impairs executive function and inhibitory motor control. Neuropsychopharmacology. 2006;31(10):2296-303. PubMed PMID: 16572123. FREE

30. Crean RD, Crane NA, Mason BJ. An evidence based review of acute and long-term effects of cannabis use on executive cognitive functions. J Addict Med. 2011;5(1):1-8. PubMed PMID: 21321675; PubMed Central PMCID: 3037578. FREE

31 Bossong MG, van Hell HH, Schubart CD, van Saane W, Iseger TA, Jager G, et al. Acute effects of 9-tetrahydrocannabinol (THC) on resting state brain function and their modulation by COMT genotype. Eur Neuropsychopharmacol. 2019;29(6):766-76. PubMed PMID: 30975584.

32. Crane NA, Schuster RM, Fusar-Poli P, Gonzalez R. Effects of cannabis on neurocognitive functioning: recent advances, neurodevelopmental influences, and sex differences. Neuropsychol Rev. 2013;23(2):117-37. PubMed PMID: 23129391; PubMed Central PMCID: 3593817. FREE

33. Mortality Risk of COVID-19 Oxford University Access date. 1/11/2021

34. Ortiz-Medina MB, Perea M, Torales J, Ventriglio A, Vitrani G, Aguilar L, et al. Cannabis consumption and psychosis or schizophrenia development. Int J Soc Psychiatry. 2018;64(7):690-704. PubMed PMID: 30442059.

35. Cascini F, Aiello C, Di Tanna G. Increasing delta-9-tetrahydrocannabinol (Delta-9-THC) content in herbal cannabis over time: systematic review and meta-analysis. Curr Drug Abuse Rev. 2012;5(1):32-40. PubMed PMID: 22150622.

36. Smart R, Caulkins JP, Kilmer B, Davenport S, Midgette G. Variation in cannabis potency and prices in a newly legal market: evidence from 30 million cannabis sales in Washington state. Addiction. 2017;112(12):2167-77. PubMed PMID: 28556310; PubMed Central PMCID: 5673542. FREE

37. Wilson J, Freeman TP, Mackie CJ. Effects of increasing cannabis potency on adolescent health. Lancet Child Adolesc Health. 2019;3(2):121-8. PubMed PMID: 30573419.

38. Surgeon General. Available from:

39. Stogner JM, Miller BL. Assessing the Dangers of “Dabbing”: Mere Marijuana or Harmful New Trend? Pediatrics. 2015;136(1):1-3. PubMed PMID: 26077476.

40. Patrick ME, Miech RA, Kloska DD, Wagner AC, Johnston LD. Trends in Marijuana Vaping and Edible Consumption From 2015 to 2018 Among Adolescents in the US. JAMA Pediatr. 2020. PubMed PMID: 32250422.

41. Schauer GL, Njai R, Grant-Lenzy AM. Modes of marijuana use – smoking, vaping, eating, and dabbing: Results from the 2016 BRFSS in 12 States. Drug Alcohol Depend. 2020;209:107900. PubMed PMID: 32061947.

42. Cannabis concentrates Wikipedia [8-12-20]. Available from:

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